Interfacial Cholesterol Binding Sites on GPCRs

GPCRs Class A [Part One]

[With residue numbers in the Ballesteros-Weinstein numbering system; Units of E, kcals/mol with molar concentration units]

PDB E Local Residues
5-hydroxytryptamine (Serotonin)  receptor 
5-Hydroxytryptamine receptor 5HT1B, inactive, Human 4iaq
4iaq_EC -13.3 V175[4.51], S179[4.55], P183[4.59], F186[4.62], H205[5.35], L207[5.37], Y208[5.38], Y211[5.41]
4iaq_IC -14.0 V74[1.57], Y86[2.41], A89[2.44], S90[2.45], V93[2.48], I170[4.46], A171[4.47], W174[4.50], I178[4.54]
-13.1 L145[3.48], Y148[3.51], W149[3.52], F219[5.49], L222[5.52], L223[5.53], A226[5.56], L227[5.57]
-12.9 L145[3.48], W149[3.52], R165[4.41], M169[4.45], L172[4.48], F176[4.52], S179[4.55], Y211[5.41]
-12.4 F217[5.47], Y218[5.48], T221[5.51], I225[5.55], Y228[5.58], Y232[5.62], I324[6.45], L328[6.49]
5-Hydroxytryptamine receptor 5HT1B, inactive, Human 4iar
4iar_EC -14.5 V175[4.51], F176[4.52], S179[4.55], P183[4.59], F186[4.62], H205[5.35], L207[5.37], Y208[5.38], Y211[5.41]
-12.8 Y40, I44, L52[1.35], L55[1.38], I59[1.42], H347[7.31], A349[7.33], F353[7.37]
4iar_IC -14.1 Y86[2.41], S90[2.45], V93[2.48], L97[2.52], L101[2.56], P163[4.39], A166[4.42], A167[4.43], I170[4.46], A171[4.47], W174[4.50]
-13.3 T64[1.47], L65[1.48], A68[1.51], F69[1.52], A72[1.55], R76[1.59], L96[2.51], I100[2.55], L383[8.57]
-13.3 W138[3.41], L145[3.48], W149[3.52], R165[4.41], M169[4.45], L172[4.48], F176[4.52], Y211[5.41], G215[5.45], F219[5.49]
-12.8 Y228[5.58], G317[6.38], L320[6.41], G321[6.42], I324[6.45], V325[6.46], L328[6.49], P329[6.50]
-13.0 I71[1.54], Y75[1.58], A89[2.44], V93[2.48], L96[2.51], L97[2.52], I100[2.55], L101[2.56]
5-Hydroxytryptamine receptor 5HT2B, inactive, with cholesterol, Human 4ib4
4ib4_EC -14.5 K53, W56[1.34], L59[1.37], L60[1.38], I115[2.65], M336[6.47], E363[7.36], I364[7.37], W367[7.40], I368[7.41], V371[7.44]
-14.2 I182[4.52], G185[4.55], I186[4.56], P189[4.59], D216[5.37], F217[5.38], F220[5.41], G221[5.42]
-12.5 L102[2.52], V126[3.23], P129[3.26], A130[3.27], F133[3.30], L134[3.31], F138[3.35], P191[4.61]
-12.3 W56[1.34], L59[1.37], L60[1.38], M63[1.41], V64[1.42], M360[7.33], I364[7.37], I368[7.41], V371[7.44]
-12.2 F331[6.42], L335[6.46], C338[6.49], P339[6.50], I342[6.53], T343[6.54], L358[7.31], L361[7.34], F365[7.38]
-12.1 F227[5.48], L230[5.51], F331[6.42], I342[6.53], I345[6.56], T346[6.57], L349[6.60], C350[6.61]
-11.9 L335[6.46], M336[6.47], P339[6.50], I342[6.53], T346[6.57], C353, L358[7.31], L361[7.34], F365[7.38]
-11.7 I61[1.39], I65[1.43], I66[1.44], I69[1.47], P109[2.59], L113[2.63], M116[2.66], F117[2.67], P122, L123
4ib4_IC -14.3 I61[1.39], I65[1.43], I66[1.44], I69[1.47], G70[1.48], T73[1.51], L77[1.55], Y394[8.57], I395[8.58], C397, Y399
-13.2 Y91[2.41], S95[2.45], V98[2.48], F133[3.30], L137[3.34], R169[4.39], F173[4.43], I176[4.46], W180[4.50]
-12.4 V151[3.48], Y154[3.51], I155[3.52], A231[5.52], I232[5.53], V235[5.56], T236[5.57], L239[5.60]
-12.4 I76[1.54], S80[1.58], M94[2.44], V98[2.48], L101[2.51], L102[2.52], L134[3.31], F138[3.35]
-12.3 L59[1.37], L60[1.38], M63[1.41], V64[1.42], P67[1.45], I368[7.41], V371[7.44], V375[7.48], V379[7.52], L382[7.55]
-12.3 W144[3.41], V151[3.48], I155[3.52], T171[4.41], K175[4.45], V178[4.48], I182[4.52], T228[5.49]
5-Hydroxytryptamine receptor 5HT2B, inactive,  with cholesterol, Human 4nc3
4nc3_EC -15.6 K53, W56[1.34], L59[1.37], L60[1.38], M63[1.41], V64[1.42], I115[2.65], E363[7.36], I364[7.37], W367[7.40], V371[7.44]
-14.8 V178[4.48], L181[4.51], I182[4.52], G185[4.55], I186[4.56], P189[4.59], K193[4.63], D216[5.37], F217[5.38], F220[5.41], G221[5.42]
-13.2 L102[2.52], P129[3.26], A130[3.27], F133[3.30], L134[3.31], F138[3.35], P191[4.61], I192[4.62]
-12.6 L332[6.43], L335[6.46], C338[6.49], P339[6.50], I342[6.53], T343[6.54], T346[6.57], L358[7.31], L361[7.34], F365[7.38]
-11.7 F227[5.48], L230[5.51], I234[5.55], F331[6.42], I342[6.53], I345[6.56], T346[6.57], L349[6.60]
-12.0 L219[5.40], L223[5.44], F227[5.48], A231[5.52], I234[5.55], V235[5.56], I345[6.56], L349[6.60]
4nc3_IC -14.6 Y91[2.41], M94[2.44], S95[2.45], V98[2.48], F133[3.30], L137[3.34], F138[3.35], F173[4.43], I176[4.46], W180[4.50], I184[4.54]
-12.9 I61[1.39], I65[1.43], I66[1.44], I69[1.47], G70[1.48], P109[2.59], L112[2.62], Y399
-12.8 I76[1.54], S80[1.58], M94[2.44], V98[2.48], L102[2.52], F106[2.56], L134[3.31], F138[3.35]
-12.6 L59[1.37], L60[1.38], M63[1.41], V64[1.42], V371[7.44], V375[7.48], V379[7.52], L382[7.55]
-12.6 V151[3.48], Y154[3.51], I155[3.52], A231[5.52], I232[5.53], V235[5.56], T236[5.57], L239[5.60]
-12.7 W144[3.41], V151[3.48], I155[3.52], K175[4.45], V178[4.48], I182[4.52], A224[5.45], T228[5.49], I232[5.53]
5-Hydroxytryptamine receptor 5HT2B, inactive,  with cholesterol,  Human 5tvn
5tvn_EC -15.3 K53, W56[1.34], L60[1.38], I115[2.65], E118, M336[6.47], E363[7.36], I364[7.37], W367[7.40], I368[7.41], V371[7.44]
-13.7 V178[4.48], L181[4.51], I182[4.52], G185[4.55], I186[4.56], P189[4.59], D216[5.37], F217[5.38], F220[5.41]
-13.3 L335[6.46], P339[6.50], I342[6.53], T343[6.54], T346[6.57], C353, L358[7.31], F365[7.38]
-12.4 F226[5.47], F227[5.48], L230[5.51], I234[5.55], F331[6.42], C338[6.49], I342[6.53], I345[6.56], T346[6.57], L349[6.60]
-12.0 L219[5.40], F220[5.41], L223[5.44], T228[5.49], A231[5.52], I232[5.53], V235[5.56], L349[6.60]
-11.7 I61[1.39], I65[1.43], I66[1.44], I69[1.47], P109[2.59], L112[2.62], L113[2.63], M116[2.66], F117[2.67], P122, L123
5tvn_IC -13.6 I61[1.39], I65[1.43], I66[1.44], I69[1.47], G70[1.48], T73[1.51], L77[1.55], Y399
-13.4 Y91[2.41], M94[2.44], S95[2.45], V98[2.48], L102[2.52], F133[3.30], L134[3.31], L137[3.34], F138[3.35], F173[4.43], I176[4.46], W180[4.50], I184[4.54]
-12.7 L60[1.38], M63[1.41], V64[1.42], M336[6.47], W367[7.40], I368[7.41], V371[7.44], V375[7.48], V379[7.52], L382[7.55]
-13.5 I76[1.54], S80[1.58], M94[2.44], V98[2.48], L102[2.52], F106[2.56], L134[3.31], F138[3.35]
-12.5 W144[3.41], V151[3.48], I155[3.52], Y166, N167, T171[4.41], I174[4.44], K175[4.45], V178[4.48], I182[4.52], T228[5.49], I232[5.53]
-12.2 V151[3.48], Y154[3.51], I155[3.52], A231[5.52], I232[5.53], V235[5.56], T236[5.57], L239[5.60]
5-Hydroxytryptamine receptor 5HT2B, inactive, with cholesterol, Human 6drx
6drx_EC -16.4 W56[1.34], L60[1.38], I115[2.65], M360[7.33], E363[7.36], I364[7.37], W367[7.40], V371[7.44]
-14.8 V178[4.48], I182[4.52], G185[4.55], I186[4.56], P189[4.59], K193[4.63], D216[5.37], F217[5.38], F220[5.41], G221[5.42]
-12.6 L335[6.46], P339[6.50], I342[6.53], T343[6.54], T346[6.57], C353, L358[7.31], L361[7.34], F365[7.38]
-12.4 L102[2.52], V126[3.23], P129[3.26], A130[3.27], F133[3.30], L134[3.31], F138[3.35], P191[4.61]
-12.0 F227[5.48], L230[5.51], I234[5.55], F331[6.42], L335[6.46], I342[6.53], I345[6.56], L349[6.60], C350[6.61]
-12.2 L219[5.40], F220[5.41], L223[5.44], F227[5.48], A231[5.52], I234[5.55], V235[5.56], I345[6.56], L349[6.60]
6drx_IC -12.6 S80[1.58], Y91[2.41], M94[2.44], S95[2.45], L137[3.34], F173[4.43], I176[4.46], W180[4.50], I184[4.54]
-12.3 W144[3.41], V151[3.48], Y154[3.51], I155[3.52], K158[3.55], T228[5.49], I232[5.53], T236[5.57], L239[5.60]
-11.7 M63[1.41], P67[1.45], V371[7.44], V375[7.48], L378[7.51], L382[7.55], F391[8.54], I395[8.58]
-12.6 L332[6.43], M336[6.47], I368[7.41], V371[7.44], V375[7.48], V379[7.52], L382[7.55], F383[7.56]
-12.0 I76[1.54], L77[1.55], S80[1.58], L81[1.59], M94[2.44], V98[2.48], L101[2.51], L102[2.52], F138[3.35]
5-Hydroxytryptamine receptor 5HT2B, inactive, with cholesterol, Human 6dry
6dry_EC -15.3 K53, W56[1.34], L59[1.37], L60[1.38], I115[2.65], M336[6.47], E363[7.36], I364[7.37], W367[7.40], I368[7.41], V371[7.44]
-13.6 I182[4.52], G185[4.55], I186[4.56], P189[4.59], D216[5.37], F217[5.38], F220[5.41], G221[5.42], A224[5.45]
-13.1 L102[2.52], P129[3.26], A130[3.27], F133[3.30], L134[3.31], F138[3.35], P191[4.61], I192[4.62]
-12.8 L335[6.46], P339[6.50], I342[6.53], T343[6.54], T346[6.57], C353, L358[7.31], F365[7.38]
-12.3 F227[5.48], L230[5.51], I234[5.55], F331[6.42], L335[6.46], I342[6.53], I345[6.56], T346[6.57], L349[6.60]
6dry_IC -14.5 W144[3.41], A148[3.45], V151[3.48], D152[3.49], I155[3.52], N167, T171[4.41], K175[4.45], V178[4.48], I182[4.52]
-13.9 Y91[2.41], M94[2.44], S95[2.45], V98[2.48], L137[3.34], F138[3.35], F173[4.43], I176[4.46], W180[4.50], I184[4.54]
-12.5 M63[1.41], P67[1.45], M336[6.47], V371[7.44], V375[7.48], L378[7.51], L382[7.55], F391[8.54], I395[8.58]
-12.9 V151[3.48], Y154[3.51], I155[3.52], T228[5.49], A231[5.52], I232[5.53], V235[5.56], T236[5.57]
-12.5 I76[1.54], L77[1.55], S80[1.58], L81[1.59], M94[2.44], V98[2.48], L101[2.51], L102[2.52], F138[3.35]
5-Hydroxytryptamine receptor 5HT2B, inactive, with cholesterol, Human 6drz
6drz_EC -14.3 W56[1.34], L60[1.38], M63[1.41], M336[6.47], I364[7.37], W367[7.40], I368[7.41], V371[7.44]
-14.0 W144[3.41], I182[4.52], I186[4.56], P189[4.59], K193[4.63], D216[5.37], F217[5.38], F220[5.41], G221[5.42], A224[5.45], T228[5.49]
-12.9 L332[6.43], L335[6.46], M336[6.47], C338[6.49], P339[6.50], I342[6.53], T343[6.54], L358[7.31], L361[7.34], F365[7.38]
-12.7 V126[3.23], P129[3.26], A130[3.27], F133[3.30], L134[3.31], L137[3.34], I188[4.58], P191[4.61]
-12.1 F227[5.48], L230[5.51], I234[5.55], F331[6.42], C338[6.49], I342[6.53], I345[6.56], T346[6.57], L349[6.60]
6drz_IC -15.6 I61[1.39], I65[1.43], I66[1.44], I69[1.47], G70[1.48], Y394[8.57], I395[8.58], C397, Y399
-14.3 W144[3.41], A148[3.45], V151[3.48], D152[3.49], I155[3.52], K175[4.45], V178[4.48], I182[4.52]
-13.5 Y91[2.41], M94[2.44], S95[2.45], V98[2.48], L102[2.52], L134[3.31], F173[4.43], I176[4.46]
-12.9 V151[3.48], Y154[3.51], I155[3.52], T228[5.49], A231[5.52], I232[5.53], V235[5.56], T236[5.57], L239[5.60]
-12.2 M63[1.41], P67[1.45], L74[1.52], M336[6.47], V371[7.44], V375[7.48], L378[7.51], L382[7.55], F391[8.54], I395[8.58]
5-Hydroxytryptamine receptor 5HT2B, inactive, with cholesterol, Human 6ds0
6ds0_EC -14.2 K53, W56[1.34], L59[1.37], L60[1.38], M63[1.41], I115[2.65], M360[7.33], E363[7.36], I364[7.37], W367[7.40], V371[7.44]
-13.0 W144[3.41], I182[4.52], G185[4.55], I186[4.56], P189[4.59], K193[4.63], F217[5.38], F220[5.41], A224[5.45], T228[5.49], I232[5.53]
-12.6 L102[2.52], V126[3.23], P129[3.26], A130[3.27], F133[3.30], L134[3.31], F138[3.35], P191[4.61]
-12.2 L335[6.46], M336[6.47], P339[6.50], I342[6.53], T343[6.54], T346[6.57], C353, F365[7.38]
6ds0_IC -14.1 I61[1.39], I65[1.43], I66[1.44], I69[1.47], G70[1.48], T73[1.51], P109[2.59], Y394[8.57], I395[8.58], C397, Y399
-13.3 Y91[2.41], M94[2.44], S95[2.45], V98[2.48], F133[3.30], L137[3.34], F173[4.43], I176[4.46], W180[4.50], I184[4.54]
-12.4 T73[1.51], I76[1.54], L77[1.55], S80[1.58], L81[1.59], L101[2.51], L105[2.55], F106[2.56]
-12.3 I76[1.54], S80[1.58], M94[2.44], V98[2.48], L101[2.51], L102[2.52], L134[3.31], F138[3.35]
-12.3 M63[1.41], P67[1.45], I368[7.41], V371[7.44], V375[7.48], L378[7.51], V379[7.52], L382[7.55]
Adenosine A1 receptor
Adenosine A1 receptor, inactive, Human 5n2s
5n2s_EC -13.1 F185[5.43], F186[5.44], L190[5.48], L193[5.51], L248[6.49], I252[6.53], C255[6.56], I256[6.57], F259[6.60]
-11.9 I13[1.36], V17[1.40], V24[1.47], A60[2.55], P64[2.59], I67[2.62], L68[2.63], I71[2.66]
-12.2 L57[2.52], L61[2.56], L65[2.60], M82[3.27], V83[3.28], P86[3.31], L90[3.35], W132[4.50], F136[4.54]
5n2s_IC -13.5 F185[5.43], L190[5.48], L193[5.51], V197[5.55], Y200[5.58], L201[5.59], F204[5.62], A237[6.38], F241[6.42], A244[6.45], L238[6.39], I252[6.53]
-13.1 V53[2.48], L57[2.52], L61[2.56], P86[3.31], A125[4.43], I128[4.46], A129[4.47], W132[4.50], F136[4.54]
Adenosine A1 receptor, inactive, residues renumbered, Human 5uen
5uen_EC -13.4 L134[4.52], V137[4.55], T141[4.59], F144[4.62], G145[4.63], W146, F183[5.41], W188[5.46]
-12.9 F185[5.43], F186[5.44], L190[5.48], L193[5.51], L194[5.52], V197[5.55], L248[6.49], I252[6.53], C255[6.56], I256[6.57], F259[6.60], C260[6.61]
-12.2 V17[1.40], A20[1.43], L21[1.44], V24[1.47], G59[2.54], A60[2.55], P64[2.59], I67[2.62], L68[2.63], I71[2.66]
5uen_IC -13.5 F185[5.43], L190[5.48], V197[5.55], F204[5.62], A237[6.38], L240[6.41], F241[6.42], A244[6.45], L248[6.49]
-13.4 I15[1.38], I19[1.42], L238[6.39], L242[6.43], F275[7.40], M283[7.48], I286[7.51], V287[7.52], F290[7.55], R291[7.56]
-12.8 G14[1.37], V17[1.40], L18[1.41], L21[1.44], W303[8.58], F307[8.62], R308[8.63], C309[8.64]
-12.5 S50[2.45], V53[2.48], L61[2.56], A125[4.43], I128[4.46], A129[4.47], W132[4.50], F136[4.54]
Adenosine A2A receptor
A2A active state no cholesterol
A2A adenosine receptor, active  state, with agonist and G protein, Human5g53
5g53_EC -13.6 S6[1.32], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], L276[7.41], T279[7.44]
-12.6 I10[1.36], L14[1.40], V18[1.44], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
-12.4 A243[6.45], L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], P266[7.31], L269[7.34]
-12.4 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
-12.3 L131[4.52], W143, Y179[5.40], F180[5.41], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
-12.1 V57[2.55], L58[2.56], F62[2.60], T65[2.63], F70, A72, G76[3.24], I80[3.28]
-12.0 F182[5.43], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
5g53_IC -13.5 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.5 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L58[2.56], F83[3.31], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-12.7 V229[6.31], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50]
-12.7 V12[1.38], L241[6.43], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52]
A2A adenosine receptor, active  state, with agonist and G protein, Human 6gdg
6gdg_EC -13.3 F182[5.43], L187[5.48], L191[5.52], L194[5.55], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-13.1 I127[4.48], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], G142[4.63], F180[5.41]
-12.1 L131[4.52], W143, Y179[5.40], F180[5.41], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
-12.8 V178[5.39], Y179[5.40], F182[5.43], F183[5.44], L187[5.48], L191[5.52], C254[6.56], F257[6.59], F258[6.60]
-12.1 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, L269[7.34], L272[7.37]
6gdg_IC -13.4 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.1 V229[6.31], A232[6.34], K233[6.35], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50]
-12.7 L96[3.44], I100[3.48], I104[3.52], L115, V116, I124[4.45], F183[5.44], A184[5.45], V188[5.49]
A2A active intermediate state no cholesterol
A2A adenosine receptor, active intermediate state, with agonist, Human 2ydo
2ydo_EC -14.4 V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], L276[7.41], T279[7.44]
-12.7 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.5 A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], P266[7.31], W268[7.33], L269[7.34]
-12.7 L14[1.40], V18[1.44], I21[1.47], P61[2.59], F62[2.60], I64[2.62], A65[2.63], F70
-12.0 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
-12.7 F93[3.41], L131[4.52], I135[4.56], Y179[5.40], F180[5.41], F183[5.44], A184[5.45], V188[5.49], P189[5.50]
2ydo_IC -13.7 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-13.5 L194[5.55], Y197[5.58], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-12.9 F182[5.43], L187[5.48], L190[5.51], L194[5.55], Y197[5.58], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L247[6.49]
A2A adenosine receptor, active intermediate state, with agonist, Human2ydv
2ydv_EC -13.9 S6[1.32], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.5 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.5 A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
-12.2 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
-12.9 L131[4.52], W143, Y179[5.40], F180[5.41], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
2ydv_IC -13.7 L194[5.55], Y197[5.58], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.3 V25[1.51], C28[1.54], W29[1.55], W32[1.58], A50[2.48], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
-13.3 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-13.0 F182[5.43], L187[5.48], L190[5.51], L194[5.55], Y197[5.58], V239[6.41], A243[6.45], L247[6.49]
-12.7 V18[1.44], I21[1.47], L22[1.48], V25[1.51], W29[1.55], V57[2.55], I302[8.57], H306[8.61]
A2A adenosine receptor, active intermediate state, with agonist, Human3qak
3qak_EC -13.7 A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], H264, A265, L269[7.34]
-12.9 V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.5 F183[5.44], L187[5.48], L191[5.52], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
3qak_IC -13.2 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], I53[2.51], V57[2.55], L58[2.56]
-12.8 Y43[2.41], S47[2.45], A50[2.48], L58[2.56], F83[3.31], L87[3.35], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-12.7 L194[5.55], Y197[5.58], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-12.6 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], I124[4.45], I127[4.48], L131[4.52], I135[4.56], F180[5.41], A184[5.45]
A2A adenosine receptor, active intermediate state, with agonist, Human4ug2
4ug2_EC -13.8 S6[1.32], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.8 L131[4.52], W143, Y179[5.40], F180[5.41], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
-12.7 G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], L269[7.34]
-12.3 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-12.1 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
4ug2_IC -13.2 V25[1.51], C28[1.54], W29[1.55], W32[1.58], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
-13.1 Y197[5.58], F201[5.62], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-12.7 Y43[2.41], L54[2.52], L58[2.56], F83[3.31], L87[3.35], K122[4.43], W129[4.50], F133[4.54]
-12.5 F183[5.44], L187[5.48], V188[5.49], L191[5.52], L192[5.53], G195[5.56], L198[5.59], R199[5.60]
-12.4 L96[3.44], I100[3.48], R120[4.41], I124[4.45], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
-12.2 V12[1.38], A15[1.41], I16[1.42], L19[1.45], V282[7.47], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
-12.8 L194[5.55], Y197[5.58], L198[5.59], F201[5.62], L202[5.63], R205[5.66], L247[6.49], I251[6.53]
A2A adenosine receptor, active intermediate state, with agonist, Human4uhr
4uhr_EC -13.5 S6[1.32], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.1 F182[5.43], L187[5.48], L190[5.51], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.8 G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, L269[7.34]
-12.6 L14[1.40], V18[1.44], I21[1.47], V57[2.55], P61[2.59], F62[2.60], A65[2.63], I80[3.28]
-12.7 L96[3.44], L131[4.52], W143, F180[5.41], F183[5.44], A184[5.45], V188[5.49], L192[5.53]
-11.8 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
4uhr_IC -13.7 T11[1.37], L14[1.40], A15[1.41], V18[1.44], L22[1.48], H306[8.61], V307[8.62], Q310[8.65]
-13.4 Y197[5.58], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.4 V25[1.51], C28[1.54], W29[1.55], W32[1.58], A50[2.48], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
-13.1 Y43[2.41], V46[2.44], A50[2.48], L54[2.52], F83[3.31], I125[4.46], W129[4.50], F133[4.54]
A2A adenosine receptor, active intermediate state, with agonist, Human5wf5
5wf5_EC -13.9 A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], S263, H264, A265, L269[7.34]
-13.5 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.3 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], V57[2.55], P61[2.59], I64[2.62]
-12.3 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
-12.3 F182[5.43], L187[5.48], L190[5.51], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
5wf5_IC -13.3 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I124[4.45], L131[4.52], I135[4.56], F180[5.41]
-13.0 L194[5.55], Y197[5.58], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.0 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-12.7 V25[1.51], C28[1.54], W29[1.55], W32[1.58], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F83[3.31]
-12.4 V12[1.38], I16[1.42], L19[1.45], L272[7.37], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, active intermediate state, with agonist, Human5wf6
5wf6_EC -13.5 G5[1.31], S6[1.32], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.6 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], G56[2.54], V57[2.55], I60[2.58], P61[2.59], I64[2.62], T65[2.63]
-12.5 G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
-12.1 I127[4.48], V130[4.51], L131[4.52], A134[4.55], T138[4.59], L141[4.62], W143, F180[5.41]
-11.9 F182[5.43], L187[5.48], L190[5.51], L191[5.52], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
5wf6_IC -14.0 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.7 L194[5.55], Y197[5.58], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.7 C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], I53[2.51], A54[2.52], L58[2.56], L87[3.35], F133[4.54]
-13.6 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L58[2.56], F83[3.31], L87[3.35], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.0 F182[5.43], L190[5.51], L194[5.55], Y197[5.58], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
A2A inactive state no cholesterol
A2A adenosine receptor, inactive state, Human 3eml
3eml_EC -14.2 L14[1.40], A17[1.43], I21[1.47], L22[1.48], I60[2.58], P61[2.59], I64[2.62], T65[2.63]
-14.2 G5[1.31], S6[1.32], V8[1.34], Y9[1.35], V12[1.38], Y271[7.36], L272[7.37], V275[7.40]
-12.8 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L194[5.55], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-12.9 G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], L269[7.34]
-12.1 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
3eml_IC -13.9 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], I251[6.53]
-13.4 Y43[2.41], V46[2.44], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.3 I237[6.39], L241[6.43], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55], R291[7.56]
-13.2 V46[2.44], S47[2.45], A50[2.48], A54[2.52], L58[2.56], F83[3.31], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
A2A adenosine receptor, inactive state, Human 3pwh
3pwh_EC -13.1 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-13.0 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, L269[7.34]
-12.3 H75[3.23], F79[3.27], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61]
-12.2 S7[1.33], I10[1.36], T11[1.37], L14[1.40], A15[1.41], V18[1.44], L19[1.45], L22[1.48]
3pwh_IC -14.5 L194[5.55], Y197[5.58], L198[5.59], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50]
-13.0 Y43[2.41], V46[2.44], A122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-12.6 L187[5.48], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-13.6 C28[1.54], W32[1.58], V46[2.44], A50[2.48], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
-13.1 I21[1.47], L22[1.48], V25[1.51], L26[1.52], W29[1.55], V57[2.55], I302[8.57], I303[8.58], S305[8.60]
-12.5 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], V116, I124[4.45], A184[5.45], C185[5.46], V188[5.49]
-12.4 Y103[3.51], V188[5.49], L191[5.52], L192[5.53], G195[5.56], V196[5.57], L198[5.59], R199[5.60]
A2A adenosine receptor, inactive state, Human 3rey
3rey_EC -15.0 L14[1.40], A17[1.43], V18[1.44], L22[1.48], P61[2.59], F62[2.60], I64[2.62], T65[2.63]
-13.2 F182[5.43], F183[5.44], L187[5.48], L194[5.55], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.8 H75[3.23], F79[3.27], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61]
-12.3 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.2 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, L269[7.34], L272[7.37], L276[7.41]
3rey_IC -13.4 I21[1.47], L22[1.48], V25[1.51], L26[1.52], W29[1.55], V57[2.55], I302[8.57], I303[8.58]
-13.4 V31[1.57], Y43[2.41], V46[2.44], A122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.0 L187[5.48], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-12.9 I237[6.39], L241[6.43], V275[7.40], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55], R291[7.56]
-12.3 F93[3.41], L96[3.44], I100[3.48], I104[3.52], I124[4.45], I135[4.56], A184[5.45], C185[5.46]
A2A adenosine receptor, inactive state, Human 3rfm
3rfm_EC -14.6 L14[1.40], A17[1.43], I21[1.47], L22[1.48], G56[2.54], P61[2.59], I64[2.62], T65[2.63]
-14.2 H75[3.23], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
-13.2 F182[5.43], F183[5.44], L187[5.48], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
3rfm_EC -14.6 I21[1.47], L22[1.48], V25[1.51], L26[1.52], W29[1.55], V57[2.55], I302[8.57], I303[8.58], R304[8.59], S305[8.60]
-14.0 L194[5.55], Y197[5.58], L198[5.59], F201[5.62], A236[6.38], G240[6.42], L244[6.46], L247[6.49]
-13.0 Y43[2.41], V46[2.44], S47[2.45], A122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-14.0 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
A2A adenosine receptor, inactive state, Human 3uza
3uza_EC -14.4 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], P61[2.59], I64[2.62], T65[2.63]
-14.2 Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48]
-13.3 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L194[5.55], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-13.2 H75[3.23], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
-12.2 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], L269[7.34], L272[7.37], L276[7.41]
-12.0 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
3uza_IC -14.0 I21[1.47], L22[1.48], V25[1.51], L26[1.52], W29[1.55], V57[2.55], I302[8.57], I303[8.58], S305[8.60]
-13.3 L194[5.55], Y197[5.58], L198[5.59], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50]
-13.2 V31[1.57], Y43[2.41], V46[2.44], A122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.1 V25[1.51], C28[1.54], W29[1.55], W32[1.58], L33[1.59], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, Human 3uzc
3uzc_EC -12.6 F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-14.3 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], P61[2.59], I64[2.62], T65[2.63]
-12.3 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], S263, A265, P266[7.31], L269[7.34]
-12.2 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.1 S47[2.45], A50[2.48], L54[2.52], L58[2.56], F79[3.27], F83[3.31], W129[4.50], F133[4.54]
3uzc_IC -14.3 L241[6.43], L272[7.37], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55], R291[7.56]
-13.6 F183[5.44], A184[5.45], V188[5.49], L191[5.52], L192[5.53], G195[5.56], L198[5.59], R199[5.60]
-13.5 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L194[5.55], A236[6.38], G240[6.42], A243[6.45], L247[6.49]
-13.5 I21[1.47], L22[1.48], V25[1.51], L26[1.52], W29[1.55], I302[8.57], I303[8.58], S305[8.60]
-13.5 V31[1.57], Y43[2.41], V46[2.44], A122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-12.6 C28[1.54], W29[1.55], V31[1.57], W32[1.58], V46[2.44], A50[2.48], L54[2.52], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, Human 3vg9
3vg9_EC -14.3 S6[1.32], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-12.7 L14[1.40], A17[1.43], I21[1.47], V57[2.55], I60[2.58], P61[2.59], I64[2.62], T65[2.63]
-12.3 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-12.1 A50[2.48], I53[2.51], A54[2.52], V57[2.55], L58[2.56], F79[3.27], F83[3.31], F133[4.54], M140[4.61]
3vg9_IC -13.9 Y43[2.41], V46[2.44], A50[2.48], L58[2.56], F83[3.31], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.7 V25[1.51], C28[1.54], W29[1.55], W32[1.58], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F83[3.31], F133[4.54]
-13.2 F93[3.41], L96[3.44], I100[3.48], R120[4.41], I124[4.45], I127[4.48], C128[4.49], L131[4.52], I135[4.56], F180[5.41], C185[5.46]
-13.2 L190[5.51], L194[5.55], F201[5.62], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
A2A adenosine receptor, inactive state, Human 3vga
3vga_EC -12.7 I10[1.36], L14[1.40], I21[1.47], V25[1.51], G56[2.54], V57[2.55], P61[2.59], I64[2.62]
-12.4 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L194[5.55], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F258[6.60]
-12.4 G240[6.42], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], L269[7.34]
-12.1 L241[6.43], L244[6.46], C245[6.47], W268[7.33], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48]
-12.2 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
3vga_IC -15.4 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L241[6.43], A243[6.45], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-14.0 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], A54[2.52], L58[2.56], F83[3.31], K122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.1 I237[6.39], L241[6.43], L244[6.46], V275[7.40], L276[7.41], T279[7.44], V283[7.48], I287[7.52], Y290[7.55]
-13.1 V12[1.38], I16[1.42], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], Y290[7.55]
-12.9 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], I53[2.51], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, Human 5uig
5uig_EC -13.5 G5[1.31], S6[1.32], V8[1.34], Y9[1.35], V12[1.38], Y271[7.36], L272[7.37], V275[7.40]
-12.7 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
5uig_IC -14.8 N42[2.40], Y43[2.41], F44[2.42], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-14.4 L241[6.43], L244[6.46], L272[7.37], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
-13.4 V25[1.51], C28[1.54], W29[1.55], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.5 F93[3.41], L96[3.44], I100[3.48], I104[3.52], I124[4.45], I127[4.48], L131[4.52], I135[4.56], F180[5.41], C185[5.46]
A2A inactive state with cholesterol
A2A adenosine receptor, inactive state, with cholesterol, Human 4eiy
4eiy_EC -14.3 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.4 F182[5.43], F183[5.44], L187[5.48], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.4 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], S263, H264, A265, L269[7.34]
-12.3 I10[1.36], L14[1.40], V18[1.44], I21[1.47], P61[2.59], I64[2.62], T65[2.63], T68[2.66]
-12.0 V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, A72, G76[3.24], I80[3.28]
4eiy_IC -14.1 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-13.5 K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.2 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56]
-13.0 F182[5.43], L187[5.48], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-12.7 V12[1.38], L241[6.43], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52]
-13.3 C28[1.54], V46[2.44], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.5 L96[3.44], I100[3.48], Y103[3.51], I104[3.52], A184[5.45], V188[5.49], P189[5.50], L192[5.53]
A2A adenosine receptor, inactive state, with cholesterol, Human 5iu4
5iu4_EC -14.4 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-14.3 I251[6.53], I252[6.54], F255[6.57], S263, H264, A265, P266[7.31], L269[7.34]
-13.2 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.9 V57[2.55], L58[2.56], F62[2.60], T65[2.63], F70, A72, G76[3.24], C77[3.25], F79[3.27], I80[3.28]
5iu4_IC -14.6 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, T117[4.38], R120[4.41], I124[4.45], P189[5.50]
-13.9 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.3 L187[5.48], L191[5.52], L194[5.55], F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
A2A adenosine receptor, inactive state, with cholesterol, Human 5iu7
5iu7_EC -14.1 A0, G5[1.31], V8[1.34], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.6 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, L269[7.34]
-12.9 F182[5.43], F183[5.44], L187[5.48], L191[5.52], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.0 I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
-12.7 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.5 V57[2.55], L58[2.56], F62[2.60], H75[3.23], G76[3.24], F79[3.27], I80[3.28], M140[4.61]
-12.2 F93[3.41], L96[3.44], F180[5.41], A184[5.45], C185[5.46], V188[5.49], P189[5.50], L192[5.53]
5iu7_IC -14.8 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], I125[4.46], W129[4.50], V130[4.51], F133[4.54]
-13.4 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.2 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, T117[4.38], I124[4.45], I135[4.56]
-12.7 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], G56[2.54], H306[8.61], V307[8.62]
-12.7 L96[3.44], I100[3.48], Y103[3.51], I104[3.52], I108[3.56], L115, V188[5.49], L192[5.53]
-12.6 I237[6.39], L241[6.43], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], I287[7.52], R291[7.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5iu8
5iu8_EC -14.8 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], C262, S263, A265, L269[7.34]
-14.7 A0, P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.4 F182[5.43], L187[5.48], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
5iu8_IC -14.8 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], I125[4.46], W129[4.50], V130[4.51], F133[4.54]
-13.6 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56], C185[5.46]
-13.2 F182[5.43], L187[5.48], L191[5.52], L194[5.55], F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-13.0 V25[1.51], C28[1.54], W29[1.55], W32[1.58], A50[2.48], I53[2.51], L54[2.52], L58[2.56], F83[3.31]
A2A adenosine receptor, inactive state, with cholesterol, Human 5iua
5iua_EC -14.4 A0, G5[1.31], V8[1.34], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-14.2 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, L269[7.34]
-13.1 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.7 V57[2.55], L58[2.56], F62[2.60], F70, A72, G76[3.24], C77[3.25], F79[3.27], I80[3.28]
-12.1 L14[1.40], I21[1.47], V57[2.55], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
-12.1 F79[3.27], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
5iua_IC -13.9 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.6 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.4 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56], C185[5.46]
-13.3 C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
-12.3 I237[6.39], L241[6.43], L244[6.46], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], I287[7.52], R291[7.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5iub
5iub_EC -14.8 I251[6.53], I252[6.54], F255[6.57], T256[6.58], S263, H264, A265, L269[7.34]
-14.7 A0, G5[1.31], V8[1.34], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.2 F182[5.43], F183[5.44], L187[5.48], L191[5.52], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.4 I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
-12.7 L14[1.40], V18[1.44], I21[1.47], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
5iub_IC -14.9 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45]
-14.0 C28[1.54], W29[1.55], V31[1.57], W32[1.58], V46[2.44], I125[4.46], W129[4.50], V130[4.51], F133[4.54]
-13.9 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.4 V25[1.51], C28[1.54], W29[1.55], W32[1.58], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
-12.7 I237[6.39], L241[6.43], L244[6.46], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], I287[7.52], R291[7.56]
-12.7 L96[3.44], I100[3.48], Y103[3.51], I104[3.52], I108[3.56], L115, V188[5.49], L192[5.53], V196[5.57]
A2A adenosine receptor, inactive state, with cholesterol, Human 5jtb
5jtb_EC -14.3 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.5 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-13.3 V57[2.55], L58[2.56], F62[2.60], T65[2.63], F70, A72, A73[3.21], G76[3.24], C77[3.25], I80[3.28]
-12.5 , L14[1.40], A17[1.43], V18[1.44], I21[1.47], V57[2.55], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
5jtb_IC -13.3 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L58[2.56], F79[3.27], F83[3.31], I125[4.46], W129[4.50], F133[4.54]
-13.0 F182[5.43], L187[5.48], L190[5.51], L194[5.55], Y197[5.58], F201[5.62], K233[6.35], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-12.6 V25[1.51], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.4 F93[3.41], L96[3.44], I100[3.48], I104[3.52], I124[4.45], L131[4.52], I135[4.56], A184[5.45], C185[5.46]
-12.3 V12[1.38], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], F286[7.51], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5k2a
5k2a_EC -15.1 A0, P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.4 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L194[5.55], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.9 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], A265, P266[7.31], L269[7.34]
-12.7 I10[1.36], L14[1.40], A17[1.43], V57[2.55], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
-12.6 V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, A72, A73[3.21], G76[3.24], C77[3.25], I80[3.28]
-12.5 A73[3.21], H75[3.23], G76[3.24], F79[3.27], V130[4.51], F133[4.54], L137[4.58], M140[4.61]
-12.4 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
5k2a_IC -14.4 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-13.6 F93[3.41], L96[3.44], A97[3.45], I100[3.48], L115, V116, R120[4.41], I124[4.45], C185[5.46], P189[5.50]
-13.0 V25[1.51], C28[1.54], W29[1.55], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.8 F182[5.43], L187[5.48], L191[5.52], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-12.5 V12[1.38], L241[6.43], L272[7.37], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
-12.5 L241[6.43], L244[6.46], C245[6.47], L272[7.37], L276[7.41], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5k2b
5k2b_EC -15.0 A0, P1[1.27], P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.9 V57[2.55], L58[2.56], F62[2.60], T65[2.63], F70, A72, A73[3.21], G76[3.24], C77[3.25], I80[3.28]
-13.8 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-13.0 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], C262, S263, A265, L269[7.34]
-12.3 H75[3.23], F79[3.27], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
5k2b_IC -14.3 Y43[2.41], F44[2.42], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-14.0 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], P189[5.50]
-13.2 V25[1.51], C28[1.54], W29[1.55], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-13.1 L187[5.48], L191[5.52], L194[5.55], F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
A2A adenosine receptor, inactive state, with cholesterol, Human 5k2c
5k2c_EC -14.2 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.5 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-13.2 F62[2.60], T65[2.63], F70, A72, G76[3.24], C77[3.25], F79[3.27], I80[3.28]
-12.5 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
-13.6 L14[1.40], A17[1.43], V18[1.44], I21[1.47], P61[2.59], I64[2.62], T65[2.63], F70
5k2c_IC -13.9 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.5 F201[5.62], K233[6.35], A236[6.38], I237[6.39], G240[6.42], L244[6.46], L247[6.49], P248[6.50], I251[6.53]
-13.3 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56]
-13.0 C28[1.54], W32[1.58], V46[2.44], A50[2.48], I53[2.51], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
A2A adenosine receptor, inactive state, with cholesterol, Human 5k2d
5k2d_EC -14.5 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.4 F182[5.43], F183[5.44], L187[5.48], L194[5.55], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-12.6 V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, A72, G76[3.24], I80[3.28]
-12.6 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, L269[7.34]
-12.5 L14[1.40], A17[1.43], V18[1.44], I21[1.47], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
-12.3 H75[3.23], W129[4.50], V130[4.51], F133[4.54], A134[4.55], L137[4.58], M140[4.61], L141[4.62]
-12.2 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
5k2d_IC -14.1 F93[3.41], L96[3.44], A97[3.45], I100[3.48], L115, V116, T117[4.38], R120[4.41], I124[4.45], P189[5.50]
-14.0 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.4 L241[6.43], L272[7.37], V275[7.40], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
-12.8 L187[5.48], L191[5.52], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-13.4 C28[1.54], W32[1.58], V46[2.44], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
A2A adenosine receptor, inactive state, with cholesterol, Human 5mzj
5mzj_EC -14.2 I251[6.53], I252[6.54], F255[6.57], S263, H264, A265, P266[7.31], L269[7.34]
-14.0 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.0 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.8 F79[3.27], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
-12.6 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.3 F93[3.41], L96[3.44], F180[5.41], A184[5.45], C185[5.46], V188[5.49], P189[5.50], L192[5.53]
-12.1 I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
5mzj_IC -14.0 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.9 C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
-13.7 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-12.8 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], V116, I124[4.45], I135[4.56]
-12.5 L241[6.43], L244[6.46], C245[6.47], L272[7.37], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
-12.2 V12[1.38], L272[7.37], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5mzp
5mzp_EC -14.1 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.0 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.7 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, L269[7.34]
-12.5 F93[3.41], L96[3.44], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], F180[5.41]
-12.4 V18[1.44], I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
5mzp_IC -13.7 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.6 C28[1.54], W29[1.55], V31[1.57], W32[1.58], V46[2.44], A50[2.48], W129[4.50], F133[4.54]
-13.3 C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
-13.1 Q89[3.37], F93[3.41], L96[3.44], A97[3.45], I100[3.48], L115, V116, R120[4.41], I124[4.45], A184[5.45], C185[5.46], P189[5.50]
-12.3 V12[1.38], L272[7.37], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5n2r
5n2r_EC -14.0 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.1 F182[5.43], F183[5.44], L187[5.48], L191[5.52], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.4 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], V57[2.55], P61[2.59], I64[2.62]
-12.3 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
-12.9 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.6 F93[3.41], L96[3.44], F180[5.41], A184[5.45], C185[5.46], V188[5.49], P189[5.50], L192[5.53]
5n2r_IC -13.9 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49]
-13.8 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.9 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], L54[2.52], V57[2.55], L58[2.56]
-12.8 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, I124[4.45], L131[4.52], I135[4.56], A184[5.45], C185[5.46]
-12.6 V25[1.51], C28[1.54], W29[1.55], W32[1.58], L33[1.59], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5nlx
5nlx_EC -13.6 G14[1.40], V17[1.43], Y18[1.44], V21[1.47], W373, Y376, L377, V380
-13.5 F191[5.52], L196[5.57], L200[5.61], L352, I356, C359, F360, F363, C364
-13.4 L349, P353, I357, F360, C367, S368, A370, L374
-12.9 F102[3.50], L140[4.61], A143, I144, T147, L150, W152, F189[5.50]
-12.5 L23[1.49], V27[1.53], I30[1.56], L31[1.57], V66[2.64], P70, I73[3.21], T74[3.22]
5nlx_IC -13.9 Y52[2.50], V55[2.53], S56[2.54], A59[2.57], L63[2.61], L67[2.65], F92[3.40], G127[4.48], A131[4.52], I134[4.55], W138[4.59], F142[4.63]
-13.6 F191[5.52], F192[5.53], L196[5.57], L199[5.60], L203[5.64], A341, G345, A348, L352
-13.6 C37, V40[2.38], W41[2.39], V55[2.53], A59[2.57], L63[2.61], V66[2.64], L67[2.65]
A2A adenosine receptor, inactive state, with cholesterol, Human 5nm2
5nm2_EC -14.3 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-14.1 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], C262, S263, A265, L269[7.34]
-13.0 F182[5.43], L187[5.48], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61], C262
-12.6 F93[3.41], L96[3.44], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], F180[5.41]
-12.3 I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
5nm2_IC -13.8 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.4 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], A122[4.43], I125[4.46], W129[4.50]
-13.2 F93[3.41], L96[3.44], A97[3.45], I100[3.48], L115, V116, I124[4.45], C185[5.46]
-13.5 C28[1.54], W32[1.58], V46[2.44], A50[2.48], I53[2.51], L54[2.52], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5nm4
5nm4_EC -14.2 P353, I356, I357, F360, C367, S368, H369, A370, L374
-13.7 G14[1.40], V17[1.43], Y18[1.44], V21[1.47], I25[1.51], W373, Y376, L377, V380, T384
-13.0 F192[5.53], L196[5.57], L200[5.61], L352, I356, C359, F360, F363, C364
-12.5 F102[3.50], L105[3.53], L140[4.61], A143, I144, T147, L150, F189[5.50]
5nm4_IC -13.9 F191[5.52], F192[5.53], L196[5.57], L199[5.60], L203[5.64], K338, A341, G345, A348, L352
-13.8 Y52[2.50], V55[2.53], S56[2.54], A59[2.57], L63[2.61], L67[2.65], F92[3.40], A131[4.52], I134[4.55], W138[4.59], F142[4.63]
-13.6 C37, W41[2.39], V55[2.53], A59[2.57], I62[2.60], L63[2.61], V66[2.64], L67[2.65]
A2A adenosine receptor, inactive state, with cholesterol, Human 5olg
5olg_EC -14.4 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.9 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], C262, S263, A265, P266[7.31], L269[7.34]
-12.9 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.6 F93[3.41], L96[3.44], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], F180[5.41]
5olg_IC -14.3 C28[1.54], W29[1.55], V31[1.57], W32[1.58], V46[2.44], A50[2.48], I125[4.46], W129[4.50], V130[4.51], F133[4.54]
-13.8 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.5 F44[2.42], F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], C128[4.49], L131[4.52], I135[4.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5olh
5olh_EC -13.8 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, P266[7.31]
-13.7 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.2 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.2 F93[3.41], L96[3.44], L131[4.52], I135[4.56], T138[4.59], L141[4.62], F180[5.41], P189[5.50]
5olh_IC -13.6 Y43[2.41], V46[2.44], S47[2.45], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.4 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
A2A adenosine receptor, inactive state, with cholesterol, Human 5olo
5olo_EC -13.0 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.0 F79[3.27], A126[4.47], W129[4.50], V130[4.51], F133[4.54], L137[4.58], M140[4.61], L141[4.62]
-12.8 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.4 L14[1.40], A17[1.43], V18[1.44], I21[1.47], L22[1.48], G56[2.54], V57[2.55], P61[2.59], I64[2.62]
-12.2 A50[2.48], L54[2.52], L58[2.56], F62[2.60], F79[3.27], F83[3.31], W129[4.50], F133[4.54]
-12.3 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
5olo_IC -14.0 Y43[2.41], V46[2.44], S47[2.45], A122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-13.9 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-12.9 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], L54[2.52], V57[2.55], L58[2.56]
-12.5 V12[1.38], I16[1.42], I237[6.39], L241[6.43], V275[7.40], T279[7.44], V283[7.48], F286[7.51], I287[7.52], R291[7.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5olv
5olv_EC -14.7 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, L269[7.34]
-13.9 L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-13.6 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
5olv_IC -13.7 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.7 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L194[5.55], A236[6.38], G240[6.42], A243[6.45], L247[6.49]
-13.5 V25[1.51], C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
-12.8 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], I124[4.45], L131[4.52], I135[4.56], A184[5.45], C185[5.46]
A2A adenosine receptor, inactive state, with cholesterol, Human 5olz
5olz_EC -13.9 G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.8 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.5 L244[6.46], P248[6.50], I252[6.54], F255[6.57], C262, A265, L269[7.34], L276[7.41]
-12.5 F93[3.41], L96[3.44], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], F180[5.41]
-12.4 I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
-12.1 L244[6.46], L247[6.49], P248[6.50], I251[6.53], I252[6.54], F255[6.57], A265, P266[7.31], L269[7.34]
5olz_IC -13.5 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], I125[4.46], W129[4.50], F133[4.54]
-13.5 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49]
-13.5 F44[2.42], F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56]
-13.4 C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F83[3.31], F133[4.54]
-12.8 L241[6.43], L244[6.46], C245[6.47], P248[6.50], L272[7.37], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5om1
5om1_EC -14.5 I251[6.53], I252[6.54], F255[6.57], T256[6.58], C262, S263, H264, A265, L269[7.34]
-13.9 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], W268[7.33], Y271[7.36], L272[7.37], V275[7.40]
-13.6 L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.6 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
-12.2 V18[1.44], I21[1.47], V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, I80[3.28]
5om1_IC -14.0 L187[5.48], L191[5.52], L194[5.55], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-13.5 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], F83[3.31], I125[4.46], W129[4.50], F133[4.54]
-13.2 C28[1.54], V31[1.57], W32[1.58], V46[2.44], A50[2.48], L54[2.52], V57[2.55], L58[2.56]
A2A adenosine receptor, inactive state, with cholesterol, Human 5om4
5om4_EC -14.7 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, L269[7.34]
-14.0 A0, G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.2 F182[5.43], F183[5.44], L187[5.48], L191[5.52], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
5om4_IC -14.1 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.7 Y43[2.41], V46[2.44], S47[2.45], A50[2.48], L54[2.52], L58[2.56], F83[3.31], A122[4.43], I125[4.46], W129[4.50], F133[4.54]
-13.3 V25[1.51], C28[1.54], W29[1.55], W32[1.58], V46[2.44], A50[2.48], L54[2.52], L58[2.56], F133[4.54]
-13.0 Q89[3.37], F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56], A184[5.45], C185[5.46], P189[5.50]
-12.5 L241[6.43], L244[6.46], C245[6.47], L272[7.37], L276[7.41], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
A2A adenosine receptor, inactive state, with cholesterol, Human 5uvi
5uvi_EC -14.3 P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.4 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], A243[6.45], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60]
-12.5 L244[6.46], P248[6.50], I251[6.53], I252[6.54], F255[6.57], S263, A265, L269[7.34]
5uvi_IC -14.2 Y43[2.41], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50], F133[4.54]
-13.3 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], F201[5.62], K233[6.35], A236[6.38], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.2 F93[3.41], L96[3.44], A97[3.45], I100[3.48], I104[3.52], L115, V116, I124[4.45], I135[4.56], A184[5.45], C185[5.46], P189[5.50]
-13.8 C28[1.54], W32[1.58], V46[2.44], A50[2.48], I53[2.51], A54[2.52], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.4 V12[1.38], L272[7.37], V275[7.40], T279[7.44], V282[7.47], V283[7.48], F286[7.51], I287[7.52]
A2A adenosine receptor, inactive state, with cholesterol, Human 5vra
5vra_EC -14.6 A0, P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], I16[1.42], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-13.5 I251[6.53], I252[6.54], F255[6.57], S263, H264, A265, P266[7.31], L269[7.34]
-13.3 F182[5.43], F183[5.44], L187[5.48], L190[5.51], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.9 I10[1.36], L14[1.40], V18[1.44], P61[2.59], I64[2.62], T65[2.63], T68[2.66], F70
-13.3 V57[2.55], L58[2.56], P61[2.59], F62[2.60], T65[2.63], F70, A72, I80[3.28]
-12.6 F93[3.41], L131[4.52], A134[4.55], I135[4.56], T138[4.59], L141[4.62], W143, F180[5.41]
5vra_IC -14.8 Y43[2.41], F44[2.42], V46[2.44], S47[2.45], K122[4.43], I125[4.46], A126[4.47], W129[4.50]
-13.5 F182[5.43], L187[5.48], L190[5.51], L191[5.52], L194[5.55], Y197[5.58], F201[5.62], A236[6.38], V239[6.41], G240[6.42], A243[6.45], L247[6.49], I251[6.53]
-13.3 F93[3.41], L96[3.44], A97[3.45], I100[3.48], L115, V116, I124[4.45], I135[4.56], A184[5.45], C185[5.46], P189[5.50]
-12.8 V25[1.51], C28[1.54], A50[2.48], I53[2.51], A54[2.52], V57[2.55], L58[2.56], F79[3.27], F83[3.31], F133[4.54]
-12.2 V8[1.34], V12[1.38], I16[1.42], L272[7.37], V275[7.40], T279[7.44], V282[7.47], F286[7.51], Y290[7.55]
-12.8 L241[6.43], L244[6.46], C245[6.47], P248[6.50], L276[7.41], V283[7.48], F286[7.51], I287[7.52]
A2A adenosine receptor, inactive state, with cholesterol, Human 6aqf
6aqf_EC -14.5 A0, P2[1.28], G5[1.31], V8[1.34], Y9[1.35], V12[1.38], L267[7.32], W268[7.33], Y271[7.36], L272[7.37], V275[7.40], T279[7.44]
-14.0 I251[6.53], I252[6.54], F255[6.57], C262, S263, H264, A265, P266[7.31], L269[7.34]
-13.1 F182[5.43], F183[5.44], L187[5.48], L191[5.52], L247[6.49], I251[6.53], C254[6.56], F255[6.57], F258[6.60], C259[6.61]
-12.2 F93[3.41], L96[3.44], L131[4.52], I135[4.56], T138[4.59], L141[4.62], F180[5.41], P189[5.50], L192[5.53]
6aqf_IC -14.7 C28[1.54], V31[1.57], W32[1.58], V46[2.44], K122[4.43], I125[4.46], A126[4.47], W129[4.50], V130[4.51], F133[4.54]
-12.7 L187[5.48], L191[5.52], L194[5.55], K233[6.35], A236[6.38], I237[6.39], G240[6.42], A243[6.45], L247[6.49]
-12.3 V12[1.38], L272[7.37], V275[7.40], T279[7.44], V283[7.48], F286[7.51], I287[7.52], Y290[7.55]
Adrenergic Beta-1 receptor
Beta-1 adrenergic, inactive, Turkey 2vt4
2vt4_EC -16.1 V172[4.56], P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.0 S45[1.36], M48[1.39], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63]
-13.6 L47[1.38], M48[1.39], L50[1.41], V51[1.42], L54[1.45], V102[2.65], W323[7.33], V326[7.36], A327[7.37], W330[7.40]
-12.3 Y217[5.48], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61], L319
2vt4_IC -13.7 L78[2.41], T81[2.44], S82[2.45], C85[2.48], K159[4.43], I162[4.46], C163[4.47], W166[4.50]
-12.8 I224[5.55], A227[5.58], L228[5.59], G293[6.38], G297[6.42], T300[6.45], L301[6.46], L304[6.49], P305[6.50], L308[6.53]
-12.5 A49[1.40], V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L356[8.57], L357[8.58]
-12.0 V60[1.51], I63[1.54], A64[1.55], G67[1.58], L88[2.51], V89[2.52], L92[2.55], L93[2.56]
-12.5 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], I168[4.52], V172[4.56], I214[5.45], P219[5.50]
Beta-1 adrenergic, inactive, partial agonist, Turkey 2y00
2y00_EC -15.1 V172[4.56], P176[4.60], W181, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.6 W40[1.31], M48[1.39], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-14.3 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66]
-12.6 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], L319
-12.4 L301[6.46], P305[6.50], L319, V320, P321[7.31], L324[7.34], F328[7.38], L331[7.41]
2y00_IC -13.6 L78[2.41], T81[2.44], S82[2.45], C85[2.48], K159[4.43], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-13.0 I224[5.55], A227[5.58], L228[5.59], Y231[5.62], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-12.7 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], A64[1.55], L356[8.57], L357[8.58]
-12.5 L50[1.41], L53[1.44], L54[1.45], A57[1.48], L61[1.52], I341[7.51], C344[7.54], R350[8.51], F353[8.54], L357[8.58]
-12.4 L54[1.45], I294[6.39], V298[6.43], A334[7.44], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
Beta-1 adrenergic, inactive, partial agonist, Turkey 2y01
2y01_EC -14.5 W40[1.31], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-14.2 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
2y01_IC -13.8 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L92[2.55], L356[8.57], L357[8.58]
-12.9 M223[5.54], I224[5.55], A227[5.58], L228[5.59], G293[6.38], I294[6.39], M296[6.41], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-12.8 L78[2.41], T81[2.44], S82[2.45], C85[2.48], V89[2.52], L93[2.56], L116[3.27], L120[3.31], K159[4.43], I162[4.46], C163[4.47], W166[4.50], F174[4.58]
-12.4 I294[6.39], V298[6.43], L301[6.46], F328[7.38], L331[7.41], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
-12.5 L46[1.37], L50[1.41], L53[1.44], L54[1.45], A57[1.48], G58[1.49], L61[1.52], C344[7.54], F353[8.54], L357[8.58]
-12.2 Y217[5.48], L221[5.52], I224[5.55], F225[5.56], L228[5.59], R229[5.60], L308[6.53], I311[6.56]
-11.9 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], V165[4.49], I168[4.52], I214[5.45], I218[5.49], I222[5.53]
Beta-1 adrenergic, inactive, agonist, Turkey 2y02
2y02_EC -14.3 P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.2 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66]
-14.2 W40[1.31], M44[1.35], M48[1.39], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-12.6 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61], L319
-12.6 L301[6.46], L304[6.49], P305[6.50], L308[6.53], L319, V320, P321[7.31], L324[7.34], F328[7.38]
2y02_IC -13.6 V52[1.43], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L92[2.55], L356[8.57], L357[8.58]
-12.9 L78[2.41], T81[2.44], S82[2.45], C85[2.48], V89[2.52], L93[2.56], L116[3.27], L120[3.31], K159[4.43], I162[4.46], C163[4.47], F174[4.58]
-12.8 I224[5.55], G293[6.38], I294[6.39], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-12.8 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I168[4.52], V172[4.56], I214[5.45], P219[5.50]
Beta-1 adrenergic, inactive, agonist, Turkey 2y03
2y03_EC -15.7 P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.4 W40[1.31], M44[1.35], M48[1.39], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-14.1 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.4 Y217[5.48], L221[5.52], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61], L319
-12.3 A206[5.37], I209[5.40], A210[5.41], I213[5.44], I214[5.45], I218[5.49], V314[6.59], F315[6.60]
-12.0 L301[6.46], L304[6.49], L308[6.53], L319, V320, P321[7.31], L324[7.34], F328[7.38]
2y03_IC -13.9 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L356[8.57], L357[8.58]
-13.6 L78[2.41], T81[2.44], S82[2.45], C85[2.48], V89[2.52], L116[3.27], L120[3.31], K159[4.43], I162[4.46], C163[4.47], W166[4.50], F174[4.58]
-12.9 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I168[4.52], V172[4.56], I214[5.45], P219[5.50]
-12.3 I224[5.55], L228[5.59], G297[6.42], T300[6.45], L301[6.46], L304[6.49], P305[6.50], L308[6.53]
-12.0 A49[1.40], L50[1.41], L53[1.44], L54[1.45], A57[1.48], L61[1.52], F353[8.54], K354[8.55], L357[8.58]
Beta-1 adrenergic, inactive, partial agonist, Turkey 2y04
2y04_EC -14.4 W40[1.31], M48[1.39], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-14.3 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-13.1 I168[4.52], L171[4.55], V172[4.56], W181, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-12.5 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60]
2y04_IC -13.6 V52[1.43], V56[1.47], A57[1.48], V60[1.51], L92[2.55], L356[8.57], L357[8.58], A358[8.59]
-13.4 M223[5.54], I224[5.55], A227[5.58], L228[5.59], G293[6.38], M296[6.41], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-13.1 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], I168[4.52], V172[4.56], I214[5.45], P219[5.50]
-12.9 T81[2.44], S82[2.45], C85[2.48], L123[3.34], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-12.4 L46[1.37], A49[1.40], L50[1.41], L53[1.44], L54[1.45], A57[1.48], G58[1.49], L61[1.52], F353[8.54], L357[8.58]
-12.1 , I294[6.39], V298[6.43], L301[6.46], L331[7.41], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
Beta-1 adrenergic, inactive, antagonist, Turkey 2ycw
2ycw_EC -14.2 M44[1.35], L47[1.38], M48[1.39], V51[1.42], L54[1.45], V102[2.65], W323[7.33], V326[7.36], A327[7.37], W330[7.40], A334[7.44], M338[7.48]
-14.1 E41[1.32], S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.6 L301[6.46], P305[6.50], V309[6.54], L319, V320, P321[7.31], L324[7.34], F328[7.38]
2ycw_IC -13.3 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L123[3.34], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-12.7 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L356[8.57], L357[8.58]
-12.2 V51[1.42], I294[6.39], V298[6.43], A334[7.44], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
-12.8 I224[5.55], G293[6.38], I294[6.39], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-12.3 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], V165[4.49], I168[4.52], V172[4.56], I214[5.45], P219[5.50]
Beta-1 adrenergic, inactive, antagonist, Turkey 2ycx
2ycx_EC -13.7 T300[6.45], L301[6.46], L304[6.49], P305[6.50], L308[6.53], V309[6.54], L319, V320, P321[7.31], L324[7.34], F328[7.38]
-13.3 W40[1.31], M44[1.35], M48[1.39], V51[1.42], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-12.9 S45[1.36], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.7 V172[4.56], P176[4.60], W181, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-12.7 Y217[5.48], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], L319
2ycx_IC -13.8 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L123[3.34], K159[4.43], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-13.7 I224[5.55], G293[6.38], M296[6.41], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-12.8 I63[1.54], A64[1.55], G67[1.58], L88[2.51], V89[2.52], L92[2.55], L93[2.56], L120[3.31]
-12.6 V160[4.44], C163[4.47], T164[4.48], A167[4.51], A170[4.54], L171[4.55], F174[4.58], L175[4.59]
-11.9 I294[6.39], V298[6.43], L301[6.46], F328[7.38], L331[7.41], M338[7.48], I342[7.52], R345[7.55]
Beta-1 adrenergic, inactive, antagonist, Turkey 2ycy
2ycy_EC -12.3 M44[1.35], V298[6.43], L301[6.46], W323[7.33], A327[7.37], F328[7.38], L331[7.41], M338[7.48]
-14.9 P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
2ycy_IC -14.3 I224[5.55], A227[5.58], L228[5.59], Y231[5.62], G297[6.42], T300[6.45], L301[6.46], L304[6.49]
-13.6 M44[1.35], L47[1.38], I294[6.39], V298[6.43], L331[7.41], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
-13.4 V52[1.43], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L92[2.55], L356[8.57], L357[8.58]
-13.3 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L116[3.27], L120[3.31], L123[3.34], I162[4.46], C163[4.47], W166[4.50], F174[4.58]
Beta-1 adrenergic, inactive, antagonist, Turkey 2ycz
2ycz_EC -15.6 P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.7 V51[1.42], L54[1.45], W323[7.33], V326[7.36], A327[7.37], W330[7.40], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-14.1 E41[1.32], S45[1.36], M48[1.39], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66]
-12.1 L301[6.46], P305[6.50], L308[6.53], V309[6.54], V312[6.57], L319, V320, L324[7.34], F328[7.38]
2ycz_IC -14.5 M223[5.54], I224[5.55], A227[5.58], L228[5.59], Y231[5.62], G293[6.38], M296[6.41], G297[6.42], T300[6.45], L301[6.46], L304[6.49]
-13.9 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L120[3.31], L123[3.34], I162[4.46], C163[4.47], W166[4.50], F174[4.58]
-13.0 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L92[2.55], L356[8.57], L357[8.58]
-12.5 V51[1.42], I294[6.39], V298[6.43], A334[7.44], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
Beta-1 adrenergic, inactive, agonist, Turkey 3zpq
3zpq_EC -14.0 I168[4.52], L171[4.55], V172[4.56], P176[4.60], W181, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-13.8 M44[1.35], L47[1.38], M48[1.39], V51[1.42], L54[1.45], V102[2.65], V326[7.36], A327[7.37], W330[7.40], A334[7.44], A337[7.47], M338[7.48]
-13.3 S45[1.36], A49[1.40], V52[1.43], L53[1.44], V56[1.47], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.8 Y217[5.48], L220[5.51], L221[5.52], L308[6.53], I311[6.56], V312[6.57], F315[6.60], L319
3zpq_IC -13.9 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L92[2.55], P96[2.59], L356[8.57], L357[8.58], A358[8.59]
-13.2 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L123[3.34], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-12.3 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], V165[4.49], I168[4.52], V172[4.56], I214[5.45]
Beta-1 adrenergic, inactive, agonist, Turkey 3zpr
3zpr_EC -16.0 V172[4.56], P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-13.7 W40[1.31], M44[1.35], L47[1.38], M48[1.39], V51[1.42], L54[1.45], V102[2.65], V326[7.36], A327[7.37], W330[7.40], L331[7.41], A334[7.44], A337[7.47], M338[7.48]
-13.3 S45[1.36], M48[1.39], A49[1.40], V52[1.43], L53[1.44], V56[1.47], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.7 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61], L319
3zpr_IC -14.0 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L92[2.55], P96[2.59], L356[8.57], L357[8.58]
-13.3 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L123[3.34], K159[4.43], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-12.4 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], V165[4.49], I168[4.52], V172[4.56], I214[5.45]
Beta-1 adrenergic, inactive, agonist, Turkey 4ami
4ami_EC -17.2 P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-13.6 E41[1.32], S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66]
-13.6 W40[1.31], M44[1.35], L47[1.38], M48[1.39], V51[1.42], L54[1.45], V102[2.65], A327[7.37], W330[7.40], A334[7.44], A337[7.47], M338[7.48], I341[7.51]
-13.2 L301[6.46], P305[6.50], L308[6.53], V309[6.54], V312[6.57], L319, V320, P321[7.31], L324[7.34], F328[7.38]
4ami_IC -13.6 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], L356[8.57], L357[8.58]
-13.1 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L123[3.34], I162[4.46], C163[4.47], W166[4.50], A170[4.54], F174[4.58]
-12.9 I224[5.55], A227[5.58], L228[5.59], G293[6.38], I294[6.39], M296[6.41], G297[6.42], T300[6.45], L304[6.49], L308[6.53]
-12.4 L46[1.37], A49[1.40], L50[1.41], L53[1.44], L54[1.45], A57[1.48], G58[1.49], L61[1.52], F353[8.54], L357[8.58]
-12.1 V134[3.45], I137[3.48], I161[4.45], T164[4.48], V165[4.49], I168[4.52], I214[5.45], I218[5.49]
Beta-1 adrenergic, inactive, agonist, Turkey 4amj
4amj_EC -17.0 V172[4.56], P176[4.60], W181, W182, N204[5.35], A206[5.37], Y207[5.38], A210[5.41], I214[5.45]
-14.0 W40[1.31], M44[1.35], L47[1.38], M48[1.39], V51[1.42], V102[2.65], W330[7.40], A334[7.44], A337[7.47], M338[7.48]
-13.2 S45[1.36], A49[1.40], V52[1.43], V56[1.47], L92[2.55], P96[2.59], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-12.6 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61], L319
4amj_IC -13.7 V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L92[2.55], L356[8.57], L357[8.58], A358[8.59]
-13.1 I224[5.55], A227[5.58], G293[6.38], M296[6.41], G297[6.42], T300[6.45], L301[6.46], L304[6.49], L308[6.53]
-13.0 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L116[3.27], L120[3.31], K159[4.43], I162[4.46], W166[4.50], F174[4.58]
-12.9 L46[1.37], A49[1.40], L50[1.41], L53[1.44], L54[1.45], A57[1.48], G58[1.49], L61[1.52], C344[7.54], F353[8.54], L357[8.58]
-12.8 E130[3.41], C133[3.44], V134[3.45], I137[3.48], I161[4.45], I168[4.52], V172[4.56], I214[5.45]
-12.4 I294[6.39], V298[6.43], L301[6.46], F328[7.38], L331[7.41], M338[7.48], I341[7.51], I342[7.52], R345[7.55]
Beta-1 adrenergic, inactive, Turkey 4gpo
4gpo_EC -14.4 L47[1.38], L50[1.41], V51[1.42], L54[1.45], W323[7.33], V326[7.36], A327[7.37], W330[7.40]
-13.1 S45[1.36], A49[1.40], V52[1.43], L53[1.44], V56[1.47], P96[2.59], A99[2.62], T100[2.63], V103[2.66]
-12.9 L301[6.46], P305[6.50], L308[6.53], V309[6.54], V312[6.57], L319, V320, L324[7.34], F328[7.38]
-12.4 V89[2.52], L116[3.27], L120[3.31], L123[3.34], W166[4.50], A170[4.54], F174[4.58], M178[4.62]
-12.0 Y217[5.48], L221[5.52], I224[5.55], L308[6.53], I311[6.56], V312[6.57], F315[6.60], N316[6.61]
4gpo_IC -13.1 L78[2.41], T81[2.44], S82[2.45], C85[2.48], L93[2.56], L120[3.31], K159[4.43], I162[4.46], C163[4.47], W166[4.50]
-12.9 L220[5.51], I224[5.55], A227[5.58], L228[5.59], Y231[5.62], G293[6.38], M296[6.41], G297[6.42], T300[6.45], L304[6.49], L308[6.53]
-12.7 C133[3.44], V134[3.45], I137[3.48], M153, I161[4.45], I213[5.44], I214[5.45], I218[5.49]
-12.3 L47[1.38], L50[1.41], V51[1.42], L54[1.45], I294[6.39], A334[7.44], M338[7.48], I341[7.51], I342[7.52]
-12.0 A49[1.40], V52[1.43], L53[1.44], V56[1.47], A57[1.48], V60[1.51], L61[1.52], A64[1.55], L356[8.57]
Beta-1 adrenergic, inactive, inverse agonist, Turkey 5a8e
5a8e_EC -15.9 S45[1.36], M48[1.39], A49[1.40], V52[1.43], L53[1.44], V56[1.47], A99[2.62], T100[2.63], V103[2.66], R104[2.67]
-14.1 W40[1.31], M44[1.35], L47[1.38], M48[1.39], V51[1.42], V102[2.65], W323[7.33], V326[7.36], A327[7.37], W330[7.40], A334[7.44]
-14.0 Q38[1.29], E41[1.32], A42[1.33], S45[1.36], L46[1.37], A49[1.40], L53[1.44], R104[2.67]
-13.7 I168[4.52], V172[4.56], P176[4.60], W181, N204[5.35], A206[5.37], Y207[5.38], I214[5.45]
-12.3 Y217[5.48], L220[5.51], L221[5.52], L304[6.49], L308[6.53], I311[6.56], V312[6.57], F315[6.60]
-12.0 L304[6.49], P305[6.50], L308[6.53], V309[6.54], V312[6.57], L319, L324[7.34], F328[7.38]
5a8e_IC -15.2 L78[2.41], F79[2.42], T81[2.44], S82[2.45], C85[2.48], K159[4.43], I162[4.46], C163[4.47], W166[4.50]
-12.7 L47[1.38], V51[1.42], L54[1.45], W330[7.40], A334[7.44], M338[7.48], I341[7.51], R345[7.55]
Adrenergic beta-2 receptor
Beta-2 adrenergic receptor, active state,  Human 3p0g
3p0g_EC -14.9 M156[4.48], V160[4.52], L163[4.55], P168[4.60], W173, Y174, N196[5.35], Y199[5.38], A202[5.41], V206[5.45]
-13.8 G280[6.42], T283[6.45], L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], V295[6.57], L302, I303, V307[7.34], L311[7.38]
-13.4 S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66], M96[2.67]
-13.1 W32[1.31], M36[1.35], V39[1.38], M40[1.39], I43[1.42], I94[2.65], I309[7.36], L310[7.37], W313[7.40], V317[7.44], F321[7.48]
-13.0 I201[5.40], I205[5.44], Y209[5.48], L212[5.51], V213[5.52], V216[5.55], I294[6.56], V297[6.59], I298[6.60]
-12.9 L155[4.47], W158[4.50], I159[4.51], G162[4.54], F166[4.58], L167[4.59], Q170[4.62], M171[4.63]
-12.2 E30[1.29], V33[1.32], V34[1.33], G37[1.36], I38[1.37], S41[1.40], L45[1.44], L95[2.66]
3p0g_IC -14.6 V216[5.55], Y219[5.58], S220[5.59], F223[5.62], M279[6.41], T283[6.45], L287[6.49], I291[6.53]
-14.1 Y70[2.41], C77[2.48], V81[2.52], A85[2.56], F108[3.27], I112[3.31], L115[3.34], I154[4.46], W158[4.50], F166[4.58]
-14.0 V52[1.51], I55[1.54], T56[1.55], A59[1.58], L80[2.51], V81[2.52], L84[2.55], A85[2.56], W105[3.24]
-13.7 Y70[2.41], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], G162[4.54], F166[4.58]
-13.4 C125[3.44], V126[3.45], V129[3.48], D130[3.49], L145, I153[4.45], M156[4.48], V160[4.52], V206[5.45], V210[5.49], I214[5.53]
Beta-2 adrenergic receptor, active state, Human 3sn6
3sn6_EC -22.8 M156[4.48], V160[4.52], L163[4.55], T164[4.56], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], V206[5.45]
-21.6 T283[6.45], L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], V295[6.57], L302, I303
-21.5 Y209[5.48], L212[5.51], V213[5.52], V216[5.55], I291[6.53], I294[6.56], V295[6.57], I298[6.60], Q299[6.61], L302
-21.0 L284[6.46], P288[6.50], V292[6.54], L302, I303, R304[7.31], V307[7.34], L311[7.38], I314[7.41]
-20.6 V44[1.43], L45[1.44], V48[1.47], P88[2.59], A92[2.63], L95[2.66], T96[2.67], F101
-21.7 Q197[5.36], I201[5.40], I205[5.44], Y209[5.48], V213[5.52], I294[6.56], V297[6.59], I298[6.60]
3sn6_IC -23.0 V216[5.55], Y219[5.58], S220[5.59], F223[5.62], L275[6.37], M279[6.41], T283[6.45], L287[6.49]
-22.3 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-21.8 Y209[5.48], L212[5.51], V216[5.55], L272[6.34], L275[6.37], G276[6.38], M279[6.41], G280[6.42], T283[6.45], L287[6.49], I291[6.53]
-21.6 F71[2.42], E122[3.41], C125[3.44], V126[3.45], V129[3.48], I153[4.45], I205[5.44], V206[5.45], V210[5.49], I214[5.53]
-22.1 V129[3.48], Y132[3.51], F133[3.52], I205[5.44], V210[5.49], V213[5.52], I214[5.53], F217[5.56], V218[5.57]
-21.1 I55[1.54], T73[2.44], C77[2.48], L80[2.51], V81[2.52], L84[2.55], A85[2.56], F108[3.27], I112[3.31]
Beta-2 adrenergic receptor, active state, Human, residues renumbered  6mxt
6mxt_EC -16.4 L163[4.55], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41]
-14.3 T283[6.45], L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], L302, I303, R304[7.31], V307[7.34], L311[7.38]
-13.9 Y209[5.48], L212[5.51], V213[5.52], I291[6.53], I294[6.56], V295[6.57], I298[6.60], Q299[6.61], L302
-12.9 L155[4.47], W158[4.50], I159[4.51], G162[4.54], F166[4.58], L167[4.59], Q170[4.62], M171[4.63]
-12.8 S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A92[2.63], L95[2.66], T96[2.67]
6mxt_IC -14.0 Y70[2.41], R151[4.43], I154[4.46], L155[4.47], W158[4.50], I159[4.51], G162[4.54], F166[4.58]
-13.5 V39[1.38], L42[1.41], I43[1.42], A46[1.45], L310[7.37], W313[7.40], I314[7.41], V317[7.44], G320[7.47], F321[7.48], L324[7.51]
-13.1 E122[3.41], C125[3.44], V126[3.45], V129[3.48], I153[4.45], I205[5.44], V206[5.45], V210[5.49], P211[5.50], I214[5.53]
-13.1 V52[1.51], I55[1.54], T56[1.55], L80[2.51], V81[2.52], L84[2.55], A85[2.56], F108[3.27], I112[3.31]
-15.7 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], F108[3.27], I154[4.46], W158[4.50]
-12.5 G276[6.38], I277[6.39], M279[6.41], G280[6.42], T283[6.45], L284[6.46], L287[6.49], I291[6.53]
-12.4 V44[1.43], L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], T56[1.55], L84[2.55], P88[2.59], L339[8.57]
Beta-2 adrenergic receptor, inactive state,  with cholesterol, Human 2rh1
2rh1_EC -13.1 L155[4.47], W158[4.50], I159[4.51], G162[4.54], L163[4.55], F166[4.58], L167[4.59], Q170[4.62], M171[4.63]
-13.0 S41[1.40], V44[1.43], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66], M96[2.67]
-12.8 W32[1.31], M36[1.35], M40[1.39], I43[1.42], I94[2.65], I309[7.36], L310[7.37], W313[7.40], V317[7.44]
2rh1_IC -14.5 Y70[2.41], C77[2.48], V81[2.52], F108[3.27], I112[3.31], L115[3.34], R151[4.43], I154[4.46], W158[4.50], F166[4.58]
-14.3 V44[1.43], L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], L84[2.55], L339[8.57], L340[8.58], C341[8.59]
-13.4 I43[1.42], A46[1.45], F49[1.48], G50[1.49], L53[1.52], V317[7.44], G320[7.47], P323[7.50], L324[7.51], F336[8.54], L340[8.58]
-13.4 I55[1.54], A59[1.58], T73[2.44], C77[2.48], L80[2.51], V81[2.52], L84[2.55], A85[2.56]
-12.4 I277[6.39], T281[6.43], L284[6.46], C285[6.47], P288[6.50], I314[7.41], F321[7.48], L324[7.51], I325[7.52], C327[7.54], R328[7.55]
Beta-2 adrenergic receptor, inactive state,  with cholesterol, Human 3d4s
3d4s_EC -17.1 T164[4.56], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], V206[5.45]
-13.8 Y209[5.48], L212[5.51], V213[5.52], L287[6.49], I291[6.53], I294[6.56], V295[6.57], I298[6.60], Q299[6.61]
-12.8 M36[1.35], V39[1.38], M40[1.39], I43[1.42], I94[2.65], E306[7.33], I309[7.36], L310[7.37], W313[7.40], V317[7.44]
-12.7 S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66]
-12.5 W32[1.31], M36[1.35], V39[1.38], I43[1.42], V317[7.44], G320[7.47], F321[7.48], L324[7.51]
-12.3 L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], V295[6.57], L302, I303
-12.7 T281[6.43], L284[6.46], C285[6.47], P288[6.50], R304[7.31], V307[7.34], L310[7.37], L311[7.38], I314[7.41]
3d4s_IC -14.5 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], F108[3.27], I112[3.31], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-13.3 V44[1.43], L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], T56[1.55], L339[8.57]
-13.0 I43[1.42], A46[1.45], F49[1.48], G50[1.49], L53[1.52], V317[7.44], G320[7.47], P323[7.50], L324[7.51], F336[8.54], Q337[8.55], L340[8.58], L342
-13.0 I55[1.54], A59[1.58], T73[2.44], C77[2.48], L80[2.51], V81[2.52], L84[2.55], A85[2.56]
Beta-2 adrenergic receptor, inactive state, with cholesterol, Human 3ny8
3ny8_EC -13.8 T281[6.43], L284[6.46], C285[6.47], P288[6.50], R304[7.31], V307[7.34], L310[7.37], L311[7.38], I314[7.41]
-13.7 T164[4.56], P168[4.60], W173, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], V206[5.45]
-13.7 T283[6.45], L284[6.46], L287[6.49], P288[6.50], V292[6.54], R304[7.31], V307[7.34], L311[7.38]
-13.4 F108[3.27], W158[4.50], I159[4.51], G162[4.54], L163[4.55], F166[4.58], L167[4.59], Q170[4.62]
-13.2 , M36[1.35], M40[1.39], I94[2.65], I309[7.36], L310[7.37], W313[7.40], I314[7.41], V317[7.44], F321[7.48]
-13.0 , S41[1.40], V44[1.43], L45[1.44], V48[1.47], P88[2.59], A91[2.62], A92[2.63], L95[2.66]
-12.4 , Y209[5.48], L212[5.51], V213[5.52], L287[6.49], I291[6.53], I294[6.56], V295[6.57], I298[6.60]
3ny8_IC -14.6 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], F108[3.27], I112[3.31], L115[3.34], A150[4.42], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-14.5 L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], T56[1.55], L84[2.55], L339[8.57], L340[8.58], C341[8.59]
-13.3 I43[1.42], A46[1.45], F49[1.48], G50[1.49], L53[1.52], V317[7.44], G320[7.47], P323[7.50], L324[7.51], F336[8.54], L340[8.58], L342
-13.1 I55[1.54], A59[1.58], T73[2.44], C77[2.48], L80[2.51], V81[2.52], L84[2.55], A85[2.56]
-12.8 F223[5.62], K273[6.35], G276[6.38], I277[6.39], G280[6.42], T283[6.45], L284[6.46], L287[6.49], I291[6.53]
-12.8 I277[6.39], T281[6.43], L284[6.46], I314[7.41], F321[7.48], L324[7.51], I325[7.52], R328[7.55]
-12.6 Y209[5.48], V213[5.52], V216[5.55], F217[5.56], S220[5.59], Q224[5.63], L287[6.49], I291[6.53]
Beta-2 adrenergic receptor, inactive state, with cholesterol, Human 3ny9
3ny9_EC -15.4 T164[4.56], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], V206[5.45]
-13.9 M36[1.35], V39[1.38], M40[1.39], I43[1.42], I94[2.65], E306[7.33], I309[7.36], L310[7.37], W313[7.40], V317[7.44], F321[7.48]
-13.6 L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], L302, I303, R304[7.31], V307[7.34], L311[7.38]
-13.4 S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66], M96[2.67]
-13.1 F108[3.27], W158[4.50], I159[4.51], G162[4.54], L163[4.55], F166[4.58], L167[4.59], Q170[4.62]
3ny9_IC -14.1 Y209[5.48], V213[5.52], V216[5.55], F217[5.56], S220[5.59], L287[6.49], I291[6.53], I294[6.56]
-13.6 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], F108[3.27], I112[3.31], L115[3.34], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-12.9 L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], L84[2.55], L339[8.57], L340[8.58]
-12.6 I55[1.54], A59[1.58], C77[2.48], L80[2.51], V81[2.52], A85[2.56], W105[3.24], I112[3.31]
-12.5 I277[6.39], T281[6.43], L284[6.46], C285[6.47], I314[7.41], F321[7.48], L324[7.51], I325[7.52]
Beta-2 adrenergic receptor, inactive state, with cholesterol, Human 3nya
3nya_EC -17.2 T164[4.56], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], V206[5.45]
-14.1 M36[1.35], V39[1.38], M40[1.39], I43[1.42], I94[2.65], E306[7.33], I309[7.36], L310[7.37], W313[7.40], V317[7.44]
-13.4 L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], V295[6.57], L302, I303, V307[7.34]
-13.3 F104[3.23], F108[3.27], W158[4.50], I159[4.51], G162[4.54], F166[4.58], Q170[4.62], M171[4.63]
-13.1 Y209[5.48], L212[5.51], L287[6.49], I291[6.53], I294[6.56], V295[6.57], I298[6.60], Q299[6.61]
-12.9 , S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66]
3nya_IC -13.4 V39[1.38], I43[1.42], A46[1.45], F49[1.48], L53[1.52], V317[7.44], G320[7.47], F321[7.48], P323[7.50], L324[7.51], C327[7.54], F336[8.54], L340[8.58]
-13.4 T73[2.44], S74[2.45], C77[2.48], F108[3.27], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-12.9 I277[6.39], T281[6.43], L284[6.46], C285[6.47], P288[6.50], L311[7.38], I314[7.41], F321[7.48], I325[7.52], R328[7.55]
-12.9 I55[1.54], A59[1.58], C77[2.48], L80[2.51], V81[2.52], A85[2.56], W105[3.24], F108[3.27], I112[3.31]
-12.7 V44[1.43], L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], T56[1.55], L339[8.57]
Beta-2 adrenergic receptor, inactive state, with cholesterol, Human 3pds
3pds_EC -12.8 L163[4.55], T164[4.56], P168[4.60], W173, N196[5.35], Y199[5.38], A202[5.41], V206[5.45]
-12.5 V44[1.43], L45[1.44], V48[1.47], F49[1.48], P88[2.59], A92[2.63], M96[2.67], F101
3pds_IC -14.1 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], I112[3.31], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-13.0 C125[3.44], V126[3.45], V129[3.48], D130[3.49], L145, I153[4.45], I205[5.44], V206[5.45], V210[5.49], I214[5.53]
-12.8 I55[1.54], A59[1.58], T73[2.44], C77[2.48], L80[2.51], V81[2.52], L84[2.55], A85[2.56]
-12.5 I277[6.39], T281[6.43], L284[6.46], C285[6.47], P288[6.50], I314[7.41], F321[7.48], I325[7.52], R328[7.55]
Beta-2 adrenergic receptor, inactive state,  with cholesterol, Human 5d5a
5d5a_EC -16.0 V160[4.52], L163[4.55], T164[4.56], P168[4.60], W173, Y174, N196[5.35], A198[5.37], Y199[5.38], A202[5.41], S203[5.42], V206[5.45]
-13.0 S41[1.40], V44[1.43], L45[1.44], V48[1.47], L84[2.55], P88[2.59], A91[2.62], A92[2.63], L95[2.66], M96[2.67]
-12.6 W32[1.31], M36[1.35], V39[1.38], I43[1.42], E306[7.33], L310[7.37], W313[7.40], V317[7.44]
-12.6 L212[5.51], L287[6.49], I291[6.53], I294[6.56], V295[6.57], I298[6.60], Q299[6.61], L302
-12.3 L115[3.34], W158[4.50], I159[4.51], G162[4.54], F166[4.58], L167[4.59], Q170[4.62], M171[4.63]
5d5a_IC -14.6 Y70[2.41], T73[2.44], S74[2.45], I112[3.31], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-13.7 V44[1.43], L45[1.44], V48[1.47], F49[1.48], V52[1.51], L53[1.52], L339[8.57], L340[8.58]
-12.9 C125[3.44], V126[3.45], V129[3.48], D130[3.49], L145, I153[4.45], V206[5.45], V210[5.49], P211[5.50], I214[5.53]
-12.7 V216[5.55], Y219[5.58], F223[5.62], G276[6.38], M279[6.41], G280[6.42], T283[6.45], L284[6.46], L287[6.49], I291[6.53]
-12.7 I55[1.54], A59[1.58], T73[2.44], C77[2.48], L80[2.51], V81[2.52], A85[2.56], W105[3.24], F108[3.27], I112[3.31]
-13.1 Y209[5.48], V213[5.52], V216[5.55], F217[5.56], S220[5.59], Q224[5.63], I291[6.53], I294[6.56]
Beta-2 adrenergic receptor, inactive state, with cholesterol, Human 5x7d
5x7d_EC -14.2 M36[1.35], V39[1.38], M40[1.39], I43[1.42], I94[2.65], K305[7.32], E306[7.33], I309[7.36], L310[7.37], W313[7.40]
-14.1 V160[4.52], T164[4.56], P168[4.60], W173, Y199[5.38], A202[5.41], S203[5.42], V206[5.45]
-13.1 L284[6.46], L287[6.49], P288[6.50], I291[6.53], V292[6.54], L302, I303, R304[7.31], V307[7.34], L311[7.38]
-12.3 L155[4.47], W158[4.50], I159[4.51], G162[4.54], L163[4.55], F166[4.58], L167[4.59], Q170[4.62], M171[4.63]
5x7d_IC -14.4 Y70[2.41], T73[2.44], S74[2.45], C77[2.48], V81[2.52], F108[3.27], I112[3.31], L115[3.34], R151[4.43], I154[4.46], L155[4.47], W158[4.50], F166[4.58]
-13.7 Y209[5.48], V213[5.52], V216[5.55], F217[5.56], S220[5.59], L287[6.49], I291[6.53], I294[6.56]
-13.1 E122[3.41], C125[3.44], V126[3.45], V129[3.48], D130[3.49], I153[4.45], V160[4.52], T164[4.56], V206[5.45], P211[5.50]
-13.1 V39[1.38], L42[1.41], I43[1.42], A46[1.45], F49[1.48], L310[7.37], V317[7.44], G320[7.47], F321[7.48], L324[7.51]
-12.6 V52[1.51], I55[1.54], T56[1.55], A59[1.58], L80[2.51], V81[2.52], L84[2.55], A85[2.56], W105[3.24], F108[3.27], I112[3.31]
Angiotensin II receptor Type 1 (AT1)
Angiotensin receptor Type II AT1, inactive, Human 4yay
4yay_EC -14.7 L155[4.52], L158[4.55], A159[4.56], L161[4.58], P162[4.59], I165[4.62], H166[4.63], E185, L195[5.38]
-12.6 Y26[1.30], P255[6.50], R275[7.26], I279[7.30], T282[7.33], A283[7.34], I286[7.37], I290[7.41]
4yay_IC -14.3 V40[1.44], F44[1.48], G45[1.49], L48[1.52], P299[7.50], Y302[7.53], G303[7.54], L305[7.56], G306[8.47]
-13.2 K240[6.35], A244[6.39], L247[6.42], F248[6.43], F251[6.46], I290[7.41], F301[7.52], F304[7.55]
-12.2 N200[5.43], F204[5.47], L205[5.48], F208[5.51], L209[5.52], L212[5.55], T213[5.56], T216[5.59], I254[6.49], Q257[6.52]
Angiotensin receptor Type II AT1, inactive, Human 4zud
4zud_EC -14.7 F117[3.41], L155[4.52], A159[4.56], P162[4.59], H166[4.63], F182, L195[5.38], T198[5.41], K199[5.42], L202[5.45]
-11.9 H24, Y26[1.30], P255[6.50], F259[6.54], D278[7.29], I279[7.30], T282[7.33], A283[7.34], I286[7.37]
-11.7 Y99[3.23], K102[3.26], I103[3.27], I150[4.47], W153[4.50], L154[4.51], G157[4.54], I164[4.61]
4zud_IC -15.3 V62[2.38], F66[2.42], C121[3.45], I124[3.48], D125[3.49], T141[4.38], V144[4.41], A145[4.42], T148[4.45], L155[4.52]
-13.6 F208[5.51], I211[5.54], L212[5.55], Y215[5.58], T216[5.59], W219[5.62], M243[6.38], L247[6.42], F250[6.45], F251[6.46], I254[6.49]
-13.4 K240[6.35], M243[6.38], A244[6.39], L247[6.42], F248[6.43], F251[6.46], I290[7.41], F301[7.52]
-13.2 F248[6.43], I290[7.41], F293[7.44], L297[7.48], L300[7.51], F301[7.52], G303[7.54], F304[7.55]
Angiotensin II receptor Type 2 (AT2)
Angiotensin receptor Type II AT2, active-like state, Human 5unf
5unf_EC -13.1 Y52[1.40], F55[1.43], F59[1.47], L91[2.51], L92[2.52], A95[2.55], P98[2.58], L99[2.59], T102[2.62], Y106[2.66], F112
-13.0 Q206[5.33], W207[5.34], G210[5.37], I211[5.38], M214[5.41], I217[5.44], L218[5.45], I222[5.49]
-12.6 M170[4.52], L173[4.55], L176[4.58], P177[4.59], Y180[4.62], F181[4.63], W207[5.34], M214[5.41], L218[5.45], I222[5.49]
5unf_IC -13.5 I81[2.41], F84[2.44], N85[2.45], V88[2.48], L92[2.52], F123[3.31], A160[4.42], S161[4.43], V164[4.46], P165[4.47]
-13.1 A260[6.39], I267[6.46], L305[7.40], L306[7.41], T309[7.44], V313[7.48], F316[7.51], L317[7.52], V321[7.56]
-12.5 Y82[2.42], C137[3.45], V140[3.48], I163[4.45], L166[4.48], M170[4.52], L218[5.45], I222[5.49], F226[5.53]
-12.5 L224[5.51], Y231[5.58], F232[5.59], A259[6.38], V262[6.41], L263[6.42], I266[6.45], L270[6.49], V274[6.53]
-12.2 I53[1.41], V56[1.44], I57[1.45], L60[1.48], V61[1.49], V64[1.52], F316[7.51], F320[7.55]
Angiotensin receptor Type II AT2, active-like state, Human 5ung
5ung_EC -13.6 Y52.B[1.40], F55.B[1.43], F59.B[1.47], I63.B[1.51], L91.B[2.51], L92.B[2.52], A95.B[2.55], P98.B[2.58], L99.B[2.59], T102.B[2.62], F112.B
-13.0 Q206.B[5.33], A209.B[5.36], G210.B[5.37], L213.B[5.40], M214.B[5.41], I217.B[5.44], L218.B[5.45], I222.B[5.49], M284.B[6.63]
-12.9 M170.B[4.52], L173.B[4.55], S174.B[4.56], L176.B[4.58], P177.B[4.59], Y180.B[4.62], M214.B[5.41], L218.B[5.45]
-12.2 I266.B[6.45], I267.B[6.46], L270.B[6.49], P271.B[6.50], V274.B[6.53], L275.B[6.54], L278.B[6.57], V292.B[7.27], V295.B[7.30], I296.B[7.31]
5ung_IC -13.3 L92.B[2.52], F123.B[3.31], L126.B[3.34], N127.B[3.35], S161.B[4.43], V164.B[4.46], P165.B[4.47], W168.B[4.50]
-13.0 I54.B[1.42], A260.B[6.39], L263.B[6.42], A264.B[6.43], I267.B[6.46], C268.B[6.47], L305.B[7.40], L306.B[7.41], T309.B[7.44], V313.B[7.48], L317.B[7.52]
-12.9 L224.B[5.51], Y231.B[5.58], F232.B[5.59], A259.B[6.38], V262.B[6.41], L263.B[6.42], I266.B[6.45], L270.B[6.49], V274.B[6.53]
-12.5 T136.B[3.44], C137.B[3.45], V140.B[3.48], I163.B[4.45], M170.B[4.52], L218.B[5.45], I222.B[5.49], F226.B[5.53]
Angiotensin receptor Type II AT2, active-like state, Human 5unh
5unh_IC -13.8 I81[2.41], N85[2.45], F123[3.31], L126[3.34], S161[4.43], V164[4.46], P165[4.47], W168[4.50]
-13.5 Y82[2.42], T136[3.44], C137[3.45], V140[3.48], I163[4.45], M170[4.52], L218[5.45], I222[5.49], F226[5.53]
-13.1 F220[5.47], I221[5.48], L224[5.51], I225[5.52], A228[5.55], T229[5.56], F232[5.59], L270[6.49], V274[6.53]
-12.7 I54[1.42], K256[6.35], A260[6.39], L263[6.42], A264[6.43], I267[6.46], C268[6.47], L305[7.40], L306[7.41], T309[7.44], V313[7.48]
-11.8 Y231[5.58], F232[5.59], R235[5.62], V262[6.41], L263[6.42], I266[6.45], L270[6.49], V274[6.53]